After his baby was born at SHG, it had murmurs which were originally thought to be benign but when Meredith Grey thought differently, she told the baby's parents. As a result, Dr. Kerr allowed Burke to take the baby on as his patient and get an echo. After the echo, it was revealed that the baby had a birth defect, tetralogy affirmed lower pulmonary atresia. Burke then booked the O.R for the following day.
He is married to his wife, Mrs. Johnson and together that have one child.